Methadone maintenance therapy and viral suppression among HIV-infected opioid users: The impacts of crack and injection cocaine use.

ABSTRACT:

Background

Methadone maintenance therapy (MMT) is associated with improved HIV treatment outcomes among people who use drugs (PWUD). The extent to which these benefits are sustained in the context of ongoing cocaine use is unclear. We assessed differential impacts of MMT on HIV viral load (VL) suppression in relation to discrete patterns of cocaine use.

Methods

Data was drawn from ACCESS, a prospective cohort of HIV-positive PWUD in Vancouver, Canada. Generalized linear mixed-effects were used to model the independent effect of MMT on VL suppression across strata of frequency of cocaine injection and crack smoking (≥daily versus ResultsThe analysis included 397 HIV-positive opioid users who completed ≥1 study interview betwe

SUBMITTER: Socias ME 

PROVIDER: S-EPMC5257247 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature