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Designing helical peptide inhibitors of protein-protein interactions.

ABSTRACT: Short helical peptides combine characteristics of small molecules and large proteins and provide an exciting area of opportunity in protein design. A growing number of studies report novel helical peptide inhibitors of protein-protein interactions. New techniques have been developed for peptide design and for chemically stabilizing peptides in a helical conformation, which frequently improves protease resistance and cell permeability. We summarize advances in peptide crosslinking chemistry and give examples of peptide design studies targeting coiled-coil transcription factors, Bcl-2 family proteins, MDM2/MDMX, and HIV gp41, among other targets.

SUBMITTER: Rezaei Araghi R

PROVIDER: S-EPMC5282971 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Designing helical peptide inhibitors of protein-protein interactions.

Rezaei Araghi Raheleh R Keating Amy E AE

Current opinion in structural biology 20160425

Short helical peptides combine characteristics of small molecules and large proteins and provide an exciting area of opportunity in protein design. A growing number of studies report novel helical peptide inhibitors of protein-protein interactions. New techniques have been developed for peptide design and for chemically stabilizing peptides in a helical conformation, which frequently improves protease resistance and cell permeability. We summarize advances in peptide crosslinking chemistry and g ...[more]

PMID: 27123812

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