Circulating antibodies to α-enolase and phospholipase A₂ receptor and composition of glomerular deposits in Japanese patients with primary or secondary membranous nephropathy.

ABSTRACT:

Background

Phospholipase A₂ receptor (PLA₂R) is recognized as a target antigen in primary membranous nephropathy (MN); Anti-α-enolase antibody in primary and secondary MN has been proposed, however, little is known about the potential contribution of α-enolase to the pathogenesis of MN.

Methods

We evaluated circulating antibodies to α-enolase by a dot blotting system and PLA₂R by indirect immunofluorescence, and glomerular deposition of these proteins in 25 patients with primary MN, 20 patients with secondary MN, 44 patients with collagen disease or severe infection, 60 patients with nephritis (each ten patients of IgA nephropathy, focal segmental gloemrulosclerosis, minimal change nephrotic syndrome, membranoproliferative glomeurlonephritis,

SUBMITTER: Kimura Y 

PROVIDER: S-EPMC5283514 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature