A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis.

ABSTRACT:

Objectives

We tested the hypothesis that a C-reactive protein and ferritin-based systemic inflammation contingency table can track mortality risk in pediatric severe sepsis.

Design

Prospective cohort study.

Setting

Tertiary PICU.

Patients

Children with 100 separate admission episodes of severe sepsis were enrolled.

Interventions

Blood samples were attained on day 2 of sepsis and bi-weekly for biomarker batch analysis. A 2 × 2 contingency table using C-reactive protein and ferritin thresholds was developed.

Measurements and main results

A C-reactive protein of 4.08 mg/dL and a ferritin of 1,980 ng/mL were found to be optimal cutoffs for outcome prediction at first sampling (n = 100) using the Youden index. PICU mortality was increased in the "high-

SUBMITTER: Carcillo JA 

PROVIDER: S-EPMC5291785 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature