Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells.

ABSTRACT: The Wnt/beta catenin pathway has been highlighted as an important player of brain tumors aggressiveness and resistance to therapies. Increasing knowledges of the regulation of beta-catenin transactivation point out its hub position in different pathophysiological outcomes in glioma such as survival and migration. Crosstalks between integrins and beta-catenin pathways have been suggested in several tumor tissues. As we demonstrated earlier that α5β1 integrin may be considered as a therapeutic target in high grade glioma through its contribution to glioma cell migration and resistance to chemotherapy, we addressed here the potential relationship between α5β1 integrin and beta-catenin activation in glioma cells. We demonstrated that overexpression and activation by fibronectin of α5β1 integri

SUBMITTER: Renner G 

PROVIDER: S-EPMC5308720 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature