The use of urinary proteomics in the assessment of suitability of mouse models for ageing.

ABSTRACT: Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can pave the way for therapeutic interventions and managing complications. Animal models such as mice are commonly used in ageing research as they have a shorter lifespan in comparison to humans and are also genetically close to humans. To assess the translatability of mouse ageing to human ageing, the urinary proteome in 89 wild-type (C57BL/6) mice aged between 8-96 weeks was investigated using capillary electrophoresis coupled to mass spectrometry (CE-MS). Using age as a continuous variable, 295 peptides significantly correlated with age in mic

SUBMITTER: Nkuipou-Kenfack E 

PROVIDER: S-EPMC5310860 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature