Ontology highlight
ABSTRACT:
SUBMITTER: Vallejo A
PROVIDER: S-EPMC5321758 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Nature communications 20170221
KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report the identification of a common transcriptional signature across mutant KRAS cancers of distinct tissue origin that includes the transcription factor FOSL1. High FOSL1 expression identifies mutant KRAS lung and pancrea ...[more]