A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.

ABSTRACT: The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.

SUBMITTER: Yesilyurt V 

PROVIDER: S-EPMC5322155 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature