B-cells with a FasL expressing regulatory phenotype are induced following successful anti-tuberculosis treatment.

ABSTRACT:

Introduction

Studies show that B-cells, in addition to producing antibodies and antigen-presentation, are able to produce cytokines as well. These include regulatory cytokines such as IL-10 by regulatory B-cells. Furthermore, a rare regulatory subset of B-cells have the potential to express FasL, which is a death-inducing ligand. This subset of B-cells have a positive role during autoimmune disease, but has not yet been studied during tuberculosis. These FasL-expressing B-cells are induced by bacterial LPS and CpG, thus we hypothesized that this phenotype might be induced during tuberculosis as well.

Methods

B-cells from participants with TB (at diagnosis and during treatment) and controls were collected, and analyzed by means of real-time PCR and flow cytometry. In addition

SUBMITTER: van Rensburg IC 

PROVIDER: S-EPMC5322165 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature