Ontology highlight
ABSTRACT: Background
Intakes of ready-to-eat cereal (RTEC) have been inversely associated with risk factors of chronic diseases such as cardiovascular disease (CVD), type 2 diabetes, and certain cancers; however, their relations with total and cause-specific mortality remain unclear.Objective
To prospectively assess the associations of RTEC intakes with all causes and disease-specific mortality risk.Design
The study included 367,442 participants from the prospective National Institutes of Health (NIH)-AARP Diet and Health Study. Intakes of RTEC were assessed at baseline.Results
Over an average of 14 years of follow-up, 46,067 deaths were documented. Consumption of RTEC was significantly associated with reduced risk of mortality from all-cause mortality and death from CVD, diabetes, all cancer, and digestive cancer (all p for trend < 0.05). In multivariate models, compared to nonconsumers of RTEC, those in the highest intake of RTEC had a 15% lower risk of all-cause mortality and 10%-30% lower risk of disease-specific mortality. Within RTEC consumers, total fiber intakes were associated with reduced risk of mortality from all-cause mortality and deaths from CVD, all cancer, digestive cancer, and respiratory disease (all p for trend < 0.005).Conclusions
Consumption of RTEC was associated with reduced risk of all-cause mortality and mortality from specific diseases such as CVD, diabetes, and cancer. This association may be mediated via greater fiber intake.
SUBMITTER: Xu M
PROVIDER: S-EPMC5325722 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature

Xu Min M Huang Tao T Lee Albert W AW Qi Lu L Cho Susan S
Journal of the American College of Nutrition 20151123 3
<h4>Background</h4>Intakes of ready-to-eat cereal (RTEC) have been inversely associated with risk factors of chronic diseases such as cardiovascular disease (CVD), type 2 diabetes, and certain cancers; however, their relations with total and cause-specific mortality remain unclear.<h4>Objective</h4>To prospectively assess the associations of RTEC intakes with all causes and disease-specific mortality risk.<h4>Design</h4>The study included 367,442 participants from the prospective National Instit ...[more]