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In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress.

ABSTRACT: The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susceptibility to oxidative stress since early CR strains had reduced in vitro survival in the presence of hydrogen peroxide and decreased catalase activity compared to that of late CR and colistin-susceptible (CS) strains.

SUBMITTER: Jones CL 

PROVIDER: S-EPMC5328574 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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<i>In Vivo</i> Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress.

Jones Crystal L CL   Singh Shweta S SS   Alamneh Yonas Y   Casella Leila G LG   Ernst Robert K RK   Lesho Emil P EP   Waterman Paige E PE   Zurawski Daniel V DV  

Antimicrobial agents and chemotherapy 20170223 3

The loss of fitness in colistin-resistant (CR) <i>Acinetobacter baumannii</i> was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susceptibility to oxidative stress since early CR strains had reduced <i>in vitro</i> survival in the presence of hydrogen peroxide and decreased catalase activity compared to that of late CR and co  ...[more]

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