Trends in Recruitment Rates for Acute Stroke Trials, 1990-2014.

ABSTRACT:

Background and purpose

Slow recruitment in acute stroke trials hampers the evaluation of new therapies and delays the adoption of effective therapies into clinical practice. This systematic review evaluates whether recruitment efficiency and rates have increased in acute stroke trials from 1990 to 2014.

Methods

Acute stroke trials from 2010 to 2014 were identified by a search of PubMed, Medline, the Cochrane Database of Research in Stroke, and the Stroke Trials Registry. These trials were compared to a previously published data set of trials conducted from 1990 to 2004.

Results

The median recruitment efficiency of trials from 1990 to 2004 was 0.41 participants/site/month compared with 0.26 participants/site/month from 2010 to 2014 (P=0.14). The median recruitme

SUBMITTER: Feldman WB 

PROVIDER: S-EPMC5330837 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature