Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure.

ABSTRACT:

Background

Inappropriately sustained inflammation is a hallmark of chronic ischemic heart failure (HF); however, the pathophysiological role of T lymphocytes is unclear.

Methods and results

Permanent coronary ligation was performed in adult C57BL/6 mice. When compared with sham-operated mice, mice with HF (8 weeks after ligation) exhibited the following features: (1) significant (P<0.05) expansion of circulating CD3⁺CD8⁺ cytotoxic and CD3⁺CD4⁺ helper (Th) T lymphocytes, together with increased Th1, Th2, Th17, and regulatory T-cell (Treg) CD4⁺ subsets; (2) significant expansion of CD8⁺ and CD4⁺ T cells in failing myocardium, with increased Th1, Th2, Th17, and Treg CD4⁺ subsets, mark

SUBMITTER: Bansal SS 

PROVIDER: S-EPMC5331621 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature