Bronchial Epithelial Cells from Asthmatic Patients Display Less Functional HLA-G Isoform Expression.

ABSTRACT: Not all asthmatic patients adequately respond to current available treatments, such as inhaled corticosteroids or omalizumab^®. New treatments will aim to target the bronchial epithelium-immune response interaction using different pathways. HLA-G is involved in immunomodulation and may promote epithelial cell differentiation and proliferation. HLA-G protein has several isoforms generated by alternative splicing that might have differential functionalities. HLA-G protein expression and genetic polymorphisms have been reported to be associated with asthma. Our hypothesis is that bronchial epithelium from asthmatic patients displays less functional HLA-G isoforms. HLA-G transcriptional isoforms were quantified by real-time PCR in human bronchial epithelium cells (HBEC) grown in air-

SUBMITTER: Carlini F 

PROVIDER: S-EPMC5333864 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature