Ontology highlight
ABSTRACT:
SUBMITTER: Blythe AJ
PROVIDER: S-EPMC5338239 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Blythe Amanda J AJ Yazar-Klosinski Berra B Webster Michael W MW Chen Eefei E Vandevenne Marylène M Bendak Katerina K Mackay Joel P JP Hartzog Grant A GA Vrielink Alice A
Protein science : a publication of the Protein Society 20160715 9
The heterodimeric transcription elongation factor Spt4/Spt5 (Spt4/5) tightly associates with RNAPII to regulate both transcriptional elongation and co-transcriptional pre-mRNA processing; however, the mechanisms by which Spt4/5 acts are poorly understood. Recent studies of the human and Drosophila Spt4/5 complexes indicate that they can bind nucleic acids in vitro. We demonstrate here that yeast Spt4/5 can bind in a sequence-specific manner to single stranded RNA containing AAN repeats. Furtherm ...[more]