Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients.

ABSTRACT:

Background

FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied the association of Foxp3 polymorphisms in severe RRP patients.

Methods

A total of 30 Korean severe RRP patients and 195 healthy controls were enrolled. Foxp3 polymorphisms (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, and rs2232365 G/A) were determined by PCR and sequencing.

Results

Genotype frequencies (GF) of rs5902434 ATT/ATT and rs2232365 GG were significantly decreased in female RRP patients than controls (0.0% vs 23.0%, p = 0.039, OR = 9.4 for both).

Conclusions

We showed that Foxp3 polymorphism of rs5902434 and rs223236

SUBMITTER: Kwon TK 

PROVIDER: S-EPMC5353865 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature