Pulmonary manifestations of chronic HPV infection in patients with recurrent respiratory papillomatosis.

ABSTRACT: Human papillomavirus (HPV) types 6 and 11 can infect the squamous epithelium of the respiratory tract. Up to 8·9% of patients with HPV-associated recurrent respiratory papillomatosis (RRP) have pulmonary involvement. Pulmonary manifestations of HPV infection are associated with considerable morbidity, in part because treatment options and management guidelines are lacking. Patients with pulmonary RRP have a 32-times increased lifetime risk of malignant transformation compared with the overall RRP population. We review the clinical and radiographic presentation, pathological features, and genetics of pulmonary RRP, and we provide management algorithms based on our clinical experience with this complex patient population. In patients with suspected pulmonary involvement, tissue-sparing proce

SUBMITTER: Pai SI 

PROVIDER: S-EPMC10634185 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature