Dysregulation of MS risk genes and pathways at distinct stages of disease.

ABSTRACT:

Objective

To perform systematic transcriptomic analysis of multiple sclerosis (MS) risk genes in peripheral blood mononuclear cells (PBMCs) of subjects with distinct MS stages and describe the pathways characterized by dysregulated gene expressions.

Methods

We monitored gene expression levels in PBMCs from 3 independent cohorts for a total of 297 cases (including clinically isolated syndromes (CIS), relapsing-remitting MS, primary and secondary progressive MS) and 96 healthy controls by distinct microarray platforms and quantitative PCR. Differential expression and pathway analyses for distinct MS stages were defined and validated by literature mining.

Results

Genes located in the vicinity of MS risk variants displayed altered expression in peripheral blood at distinc

SUBMITTER: Srinivasan S 

PROVIDER: S-EPMC5356498 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature