Ontology highlight
ABSTRACT:
SUBMITTER: Adams Waldorf KM
PROVIDER: S-EPMC5365281 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nature medicine 20160912 11
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic eval ...[more]