5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis.

ABSTRACT:

Background

5α-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5α-reductase activity in PCOS subjects and the relationship between 5α-reductase activity and body mass index (BMI), insulin resistance (IR) remain largely unknown.

Methods

We performed a meta-analysis to examine 5α-reductase activity in women with PCOS; exploratory subgroup analyses were also performed.

Results

Five articles (with 356 cases and 236 controls) reporting 5α-reductase activity in patients with PCOS were selected for the meta-analysis. We observed significantly higher ratios of 5αTHF/THF (5α-reduced tetrahydrocortisol to 5β-reduced tetrahydrocortisol) and An/Et (androsteroneto/etiocholanolone) levels, which were used to a

SUBMITTER: Wu C 

PROVIDER: S-EPMC5369013 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature