M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

ABSTRACT: In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in blood from a unique cohort of patients, comprising previously healthy individuals hospitalized with and without respiratory failure during one influenza season, and infected with one specific influenza A strain. This analysis was compared with similarly hospitalized influenza patients with known risk factors (total of n = 60 patients recruited). We found a sustained increase in a specific subset of proinflammatory monocytes, with high TNF-α expression and an M1-like phenotype (independent of viral titers), in these previously healthy patients with sever

SUBMITTER: Cole SL 

PROVIDER: S-EPMC5374077 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature