HPV-6 Molecular Variants Association With the Development of Genital Warts in Men: The HIM Study.

ABSTRACT:

Background

Human papillomavirus type 6 (HPV-6) and HPV-11 are the etiological agents of approximately 90% of genital warts (GWs). The impact of HPV-6 genetic heterogeneity on persistence and progression to GWs remains undetermined.

Methods

HPV Infection in Men (HIM) Study participants who had HPV-6 genital swabs and/or GWs preceded by a viable normal genital swab were analyzed. Variants characterization was performed by polymerase chain reaction sequencing and samples classified within lineages (A, B) and sublineages (B1, B2, B3, B4, B5). Country- and age-specific analyses were conducted for individual variants; odds ratios and 95% confidence intervals for the risk of GWs according to HPV-6 variants were calculated.

Results

B3 variants were most prevalent. HPV-6 varia

SUBMITTER: Flores-Diaz E 

PROVIDER: S-EPMC5388291 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature