The biological knowledge discovery by PCCF measure and PCA-F projection.
Ontology highlight
ABSTRACT:
SUBMITTER: Jia X
PROVIDER: S-EPMC5388332 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
The biological knowledge discovery by PCCF measure and PCA-F projection.
Jia Xingang X Zhu Guanqun G Han Qiuhong Q Lu Zuhong Z
PloS one 20170411 4
In the process of biological knowledge discovery, PCA is commonly used to complement the clustering analysis, but PCA typically gives the poor visualizations for most gene expression data sets. Here, we propose a PCCF measure, and use PCA-F to display clusters of PCCF, where PCCF and PCA-F are modeled from the modified cumulative probabilities of genes. From the analysis of simulated and experimental data sets, we demonstrate that PCCF is more appropriate and reliable for analyzing gene expressi ...[more]
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