Ontology highlight
ABSTRACT:
SUBMITTER: Dobber A
PROVIDER: S-EPMC5392771 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20170315 4
Photoremovable protecting groups added to bioactive molecules provide spatial and temporal control of the biological effects. We present synthesis and characterization of the first photoactivatable small-molecule tubulin inhibitor. By blocking the pharmacophoric OH group on compound <b>1</b> with photoremovable 4,5-dimethoxy-2-nitrobenzyl moiety we developed the photocaged prodrug <b>2</b> that had no effect in biological assays. Short UV light exposure of the derivative <b>2</b> or UV-irradiati ...[more]