The Relation Between Inflation in Type-I and Type-II Error Rate and Population Divergence in Genome-Wide Association Analysis of Multi-Ethnic Populations.

ABSTRACT: Population divergence impacts the degree of population stratification in Genome Wide Association Studies. We aim to: (i) investigate type-I error rate as a function of population divergence (F_ST) in multi-ethnic (admixed) populations; (ii) evaluate the statistical power and effect size estimates; and (iii) investigate the impact of population stratification on the results of gene-based analyses. Quantitative phenotypes were simulated. Type-I error rate was investigated for Single Nucleotide Polymorphisms (SNPs) with varying levels of F_ST between the ancestral European and African populations. Type-II error rate was investigated for a SNP characterized by a high value of F_ST. In all tests, genomic MDS components were included to correct for population strati

SUBMITTER: Derks EM 

PROVIDER: S-EPMC5403879 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature