Comparison of the King's and MiToS staging systems for ALS.

ABSTRACT:

Objective

To investigate and compare two ALS staging systems, King's clinical staging and Milano-Torino (MiToS) functional staging, using data from the LiCALS phase III clinical trial (EudraCT 2008-006891-31).

Methods

Disease stage was derived retrospectively for each system from the ALS Functional Rating Scale-Revised subscores using standard methods. The two staging methods were then compared for timing of stages using box plots, correspondence using chi-square tests, agreement using a linearly weighted kappa coefficient and concordance using Spearman's rank correlation.

Results

For both systems, progressively higher stages occurred at progressively later proportions of the disease course, but the distribution differed between the two methods. King's stage 3 corresp

SUBMITTER: Fang T 

PROVIDER: S-EPMC5425622 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature