Maternal plasma polyunsaturated fatty acid levels during pregnancy and childhood lipid and insulin levels.

ABSTRACT:

Background and aims

Maternal polyunsaturated fatty acid (PUFA) levels are associated with cord blood lipid and insulin levels. Not much is known about the influence of maternal PUFAs during pregnancy on long-term offspring lipid and insulin metabolism. We examined the associations of maternal plasma n-3 and n-6 PUFA levels during pregnancy with childhood lipid and insulin levels.

Methods and results

In a population-based prospective cohort study, among 3230 mothers and their children, we measured maternal second trimester n-3 and n-6 PUFA plasma levels. At the median age of 6.0 years (95% range, 5.6-7.9), we measured childhood total-cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglyceride, insulin and c-peptide levels.

SUBMITTER: Vidakovic AJ 

PROVIDER: S-EPMC5426534 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature