A Retrospective Study of Progression-Free and Overall Survival in Pediatric Medulloblastoma Based on Molecular Subgroup Classification: A Single-Institution Experience.

ABSTRACT:

Background

Medulloblastoma (MB) has been classified into four core subgroups according to the transcriptional profile in recent years. However, some disagreement among researchers remains regarding the prognoses and most effective treatments of the different subgroups with different age distributions.

Objective

The objective of this study was to analyze MB prognosis in children population based on the classification of four molecular subgroups.

Methods

From January 2011 to January 2013, 84 consecutive MB patients aged underwent tumor removal at Beijing Tiantan Hospital. A total of 55 patients who ranged in age from 4 to 18 years underwent detailed follow-up. Molecular subgrouping was performed using RT-PCR.

Results

The 2-year progression-free survival (PFS) and

SUBMITTER: Jiang T 

PROVIDER: S-EPMC5427081 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature