Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.

ABSTRACT: Cardiovascular dysfunction is highly comorbid with mood disorders, such as anxiety and depression. However, the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood. In this study, we used mice bearing a knock-in sarcomeric mutation, which is exhibited in human hypertrophic cardiomyopathy (HCM), to investigate the influence of HCM over the development of anxiety and depression. We employed behavioral, MRI, and biochemical techniques in young (3-4 mo) and aged adult (7-8 mo) female mice to examine the effects of HCM on the development of anxiety- and depression-like behaviors. We focused on females because in both humans and rodents, they experience a 2-fold increase in mood disorder prevalence vs. males. Our result

SUBMITTER: Dossat AM 

PROVIDER: S-EPMC5434648 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature