Mild and Selective C-H Activation of COC Microfluidic Channels Allowing Covalent Multifunctional Coatings.

ABSTRACT: Plastics, such as cyclic olefin copolymer (COC), are becoming an increasingly popular material for microfluidics. COC is used, in part, because of its (bio)-chemical resistance. However, its inertness and hydrophobicity can be a major downside for many bioapplications. In this paper, we show the first example of a surface-bound selective C-H activation of COC into alcohol C-OH moieties under mild aqueous conditions at room temperature. The nucleophilic COC-OH surface allows for subsequent covalent attachments, such as of a H-terminated silane. The resulting hybrid material (COC-Si-H) was then modified via a photolithographic hydrosilylation in the presence of ω-functionalized 1-alkenes to form a new highly stable, solvent-resistant hybrid surface.

SUBMITTER: Carvalho RR 

PROVIDER: S-EPMC5437660 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature