Ontology highlight
ABSTRACT:
SUBMITTER: Cao F
PROVIDER: S-EPMC5438348 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Scientific reports 20170519 1
Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chromatin interactions. Super-enhancers and broad H3K4me3 domains showed higher association with chromatin interactions than their typical counterparts. Interestingly, we identified a subset of super-enhan ...[more]