Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in Humans.

ABSTRACT:

Rationale

Air pollution has been associated with increased prevalence of type 2 diabetes; however, the mechanisms remain unknown. We have shown that acute ozone exposure in rats induces release of stress hormones, hyperglycemia, leptinemia, and glucose intolerance that are associated with global changes in peripheral glucose, lipid, and amino acid metabolism.

Objectives

To examine ozone-induced metabolic derangement in humans using serum metabolomic assessment, establish human-to-rodent coherence, and identify novel nonprotein biomarkers.

Methods

Serum samples were obtained from a crossover clinical study that included two clinic visits (n = 24 each) where each subject was blindly exposed in the morning to either filtered air or 0.3 parts per million ozone for 2 hours

SUBMITTER: Miller DB 

PROVIDER: S-EPMC5440058 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature