AGeNNT: annotation of enzyme families by means of refined neighborhood networks.

ABSTRACT:

Background

Large enzyme families may contain functionally diverse members that give rise to clusters in a sequence similarity network (SSN). In prokaryotes, the genome neighborhood of a gene-product is indicative of its function and thus, a genome neighborhood network (GNN) deduced for an SSN provides strong clues to the specific function of enzymes constituting the different clusters. The Enzyme Function Initiative ( http://enzymefunction.org/ ) offers services that compute SSNs and GNNs.

Results

We have implemented AGeNNT that utilizes these services, albeit with datasets purged with respect to unspecific protein functions and overrepresented species. AGeNNT generates refined GNNs (rGNNs) that consist of cluster-nodes representing the sequences under study and Pfam-nodes r

SUBMITTER: Kandlinger F 

PROVIDER: S-EPMC5445326 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature