Ontology highlight
ABSTRACT:
SUBMITTER: Plata G
PROVIDER: S-EPMC3696893 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Nature chemical biology 20121001 10
Annotation of organism-specific metabolic networks is one of the main challenges of systems biology. Importantly, owing to inherent uncertainty of computational annotations, predictions of biochemical function need to be treated probabilistically. We present a global probabilistic approach to annotate genome-scale metabolic networks that integrates sequence homology and context-based correlations under a single principled framework. The developed method for global biochemical reconstruction usin ...[more]