ANRIL Genetic Variants in Iranian Breast Cancer Patients.

ABSTRACT:

Objective

The genetic variants of the long non-coding RNA ANRIL (an antisense noncoding RNA in the INK4 locus) as well as its expression have been shown to be associated with several human diseases including cancers. The aim of this study was to examine the association of ANRIL variants with breast cancer susceptibility in Iranian patients.

Materials and methods

In this case-control study, we genotyped rs1333045, rs4977574, rs1333048 and rs10757278 single nucleotide polymorphisms (SNPs) in 122 breast can- cer patients as well as in 200 normal age-matched subjects by tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR).

Results

The TT genotype at rs1333045 was significantly over-represented among pa- tients (P=0.038

SUBMITTER: Khorshidi HR 

PROVIDER: S-EPMC5448323 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature