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Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior.

ABSTRACT: We tested the relation between pain behavior, theta (4-8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.

SUBMITTER: LeBlanc BW 

PROVIDER: S-EPMC5449396 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior.

LeBlanc Brian W BW   Cross Brent B   Smith Kelsey A KA   Roach Catherine C   Xia Jimmy J   Chao Yu-Chieh YC   Levitt Joshua J   Koyama Suguru S   Moore Christopher I CI   Saab Carl Y CY  

Scientific reports 20170530 1

We tested the relation between pain behavior, theta (4-8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience. ...[more]

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