SUV-quantification of physiological lung tissue in an integrated PET/MR-system: Impact of lung density and bone tissue.

ABSTRACT:

Purpose

The aim of the study was to investigate the influence of lung density changes as well as bone proximity on the attenuation correction of lung standardized uptake values (SUVs).

Methods and materials

15 patients with mostly oncologic diseases were examined in 18F-FDG-PET/CT and subsequently in a fully integrated PET/MR scanner. From each PET dataset acquired in PET/MR, four different PET reconstructions were computed using different attenuation maps (μ-maps): i) CT-based μ-map (gold standard); ii) CT-based μ-map in which the linear attenuation coefficients (LAC) of the lung tissue was replaced by the lung LAC from the MR-based segmentation method; iii) based on reconstruction ii), the LAC of bone structures was additionally replaced with the LAC from the MR-based segm

SUBMITTER: Seith F 

PROVIDER: S-EPMC5451041 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature