Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC5457515 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature communications 20170523
STING (also known as MITA) is critical for host defence against viruses and the activity of STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully understood. Here, we show that ubiquitin-specific protease 13 (USP13) is a STING-interacting protein that catalyses deubiquitination of STING. Knockdown or knockout of USP13 potentiates activation of IRF3 and NF-κB and expression of downstream genes after HSV-1 infection or transfection of DNA ligands. USP13 deficien ...[more]