Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of aqp-8 in C. elegans.

ABSTRACT: Aquaporins occupy an essential role in sustaining the salt/water balance in various cells types and tissues. Here, we present new insights into aqp-8 expression and regulation in Caenorhabditis elegans. We show, that upon exposure to osmotic stress, aqp-8 exhibits a distinct expression pattern within the excretory cell compared to other C. elegans aquaporins expressed. This expression is correlated to the osmolarity of the surrounding medium and can be activated physiologically by osmotic stress or genetically in mutants with constitutively active osmotic stress response. In addition, we found aqp-8 expression to be constitutively active in the TRPV channel mutant osm-9(ok1677). In a genome-wide RNAi screen we identified additional regulators of

SUBMITTER: Igual Gil C 

PROVIDER: S-EPMC5465262 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature