Ontology highlight
ABSTRACT:
SUBMITTER: Tan H
PROVIDER: S-EPMC5466820 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Tan Haiyan H Yang Kai K Li Yuxin Y Shaw Timothy I TI Wang Yanyan Y Blanco Daniel Bastardo DB Wang Xusheng X Cho Ji-Hoon JH Wang Hong H Rankin Sherri S Guy Cliff C Peng Junmin J Chi Hongbo H
Immunity 20170309 3
The molecular circuits by which antigens activate quiescent T cells remain poorly understood. We combined temporal profiling of the whole proteome and phosphoproteome via multiplexed isobaric labeling proteomics technology, computational pipelines for integrating multi-omics datasets, and functional perturbation to systemically reconstruct regulatory networks underlying T cell activation. T cell receptors activated the T cell proteome and phosphoproteome with discrete kinetics, marked by early d ...[more]