Identification and characterization of a rich population of CD34⁺ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands.

ABSTRACT: Mesenchymal stem/stromal cells (MSCs) play crucial roles in maintaining tissue homeostasis during physiological turnovers and injuries. Very little is known about the phenotype, distribution and molecular nature of MSCs in freshly isolated human salivary glands (SGs) as most reports have focused on the analysis of cultured MSCs. Our results demonstrate that the cell adhesion molecule CD34 was widely expressed by the MSCs of human major SGs, namely parotid (PAG), sublingual (SLG) and submandibular (SMG) glands. Further, gene expression analysis of CD34⁺ cells derived from fetal SMGs showed significant upregulation of genes involved in cellular adhesion, proliferation, branching, extracellular matrix remodeling and organ development. Moreover, CD34⁺ SMG cells exhibited

SUBMITTER: Togarrati PP 

PROVIDER: S-EPMC5471181 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature