Nicotinamide Administration Improves Remyelination after Stroke.

ABSTRACT:

Aims

Stroke is a leading cause of morbidity and mortality. This study aimed to determine whether nicotinamide administration could improve remyelination after stroke and reveal the underlying mechanism.

Methods

Adult male C57BL/6J mice were intraperitoneally (i.p.) administered with nicotinamide (200 mg/kg, daily) or saline after stroke induced by photothrombotic occlusion of the middle cerebral artery. FK866 (3 mg/kg, daily, bis in die), an inhibitor of NAMPT, and ANA-12 (0.5 mg/kg, daily), an antagonist of tropomyosin-related kinase B (TrkB), were administered intraperitoneally 1 h before nicotinamide administration. Functional recovery, MRI, and histological assessment were performed after stroke at different time points.

Results

The nicotinamide-treated mic

SUBMITTER: Wang C 

PROVIDER: S-EPMC5471593 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature