Differential regulations of vestibulo-ocular reflex and optokinetic response by β- and α2-adrenergic receptors in the cerebellar flocculus.

ABSTRACT: Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and optokinetic response (OKR) have been studied as models of cerebellum-dependent motor learning. Previous studies showed the involvement of adrenergic systems in the regulation of VOR, OKR and cerebellar synaptic functions. Here, we show differential contributions of β- and α2-adrenergic receptors in the mouse cerebellar flocculus to VOR and OKR control. Effects of application of β- or α2-adrenergic agonist or antagonist into the flocculus suggest that the β-adrenergic receptor activity maintains the VOR gain at high levels and contributes to adaptation o

SUBMITTER: Wakita R 

PROVIDER: S-EPMC5479797 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature