Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment.

ABSTRACT:

Aims/hypothesis

Serum extracellular nicotinamide phosphoribosyltransferase (eNAMPT) concentrations are elevated in type 2 diabetes. However, the relationship between abnormally elevated serum eNAMPT and type 2 diabetes pathophysiology is unclear. eNAMPT circulates in functionally and structurally distinct monomeric and dimeric forms. Dimeric eNAMPT promotes NAD biosynthesis. The role of eNAMPT-monomer is unclear but it may have NAD-independent proinflammatory effects. However, studies of eNAMPT in type 2 diabetes have not distinguished between monomeric and dimeric forms. Since type 2 diabetes is characterised by chronic inflammation, we hypothesised a selective NAD-independent role for eNAMPT-monomer in type 2 diabetes.

Methods

Two mouse models were used to examine the role

SUBMITTER: Kieswich J 

PROVIDER: S-EPMC5506101 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature