The performance of the GAP model in patients with rheumatoid arthritis associated interstitial lung disease.

ABSTRACT:

Background

Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is associated with significant morbidity and mortality. Similarities have been observed between patients with idiopathic pulmonary fibrosis (IPF) and the UIP (usual interstitial pneumonia) form of RA-ILD. The GAP (gender, age, physiology) model has been shown to predict mortality in patients with IPF, but its ability to predict mortality in RA-ILD is not known.

Methods

We identified 309 patients with RA-ILD at 4 academic centers with ongoing longitudinal cohorts of patients with ILD. The primary endpoint was mortality. To handle missing data (n = 219 subjects with complete dataset), multiple imputation by iterative chained equations was used. Using the GAP model as a baseline, we assessed improveme

SUBMITTER: Morisset J 

PROVIDER: S-EPMC5506836 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature