Targeting the epigenome: Screening bioactive compounds that regulate histone deacetylase activity.

ABSTRACT:

Scope

Nutrigenomics is a rapidly expanding field that elucidates the link between diet-genome interactions. Recent evidence demonstrates that regulation of the epigenome, and in particular inhibition of histone deacetylases (HDACs), impact pathogenetic mechanisms involved in chronic disease. Few studies, to date, have screened libraries of bioactive compounds that act as epigenetic modifiers. This study screened a library of 131 natural compounds to determine bioactive compounds that inhibit Zn-dependent HDAC activity.

Methods and results

Using class-specific HDAC substrates, we screened 131 natural compounds for HDAC activity in bovine cardiac tissue. From this screen, we identified 18 bioactive compound HDAC inhibitors. Using our class-specific HDAC substrates, we next scr

SUBMITTER: Godoy LD 

PROVIDER: S-EPMC5508980 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature