Vitamin D insufficiency in neonatal hypoxic-ischemic encephalopathy.

ABSTRACT:

Background

Vitamin D has neuroprotective and immunomodulatory properties, and deficiency is associated with worse stroke outcomes. Little is known about effects of hypoxia-ischemia or hypothermia treatment on vitamin D status in neonates with hypoxic-ischemic encephalopathy (HIE). We hypothesized vitamin D metabolism would be dysregulated in neonatal HIE altering specific cytokines involved in Th17 activation, which might be mitigated by hypothermia.

Methods

We analyzed short-term relationships between 25(OH) and 1,25(OH)₂ vitamin D, vitamin D binding protein, and cytokines related to Th17 function in serum samples from a multicenter randomized controlled trial of hypothermia 33 ^°C for 48 h after HIE birth vs. normothermia in 50 infants with moderate to

SUBMITTER: Lowe DW 

PROVIDER: S-EPMC5509506 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature