Ontology highlight
ABSTRACT:
SUBMITTER: Hartlmuller C
PROVIDER: S-EPMC5511288 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20170714 1
NMR spectroscopy is a powerful technique to study ribonucleic acids (RNAs) which are key players in a plethora of cellular processes. Although the NMR toolbox for structural studies of RNAs expanded during the last decades, they often remain challenging. Here, we show that solvent paramagnetic relaxation enhancements (sPRE) induced by the soluble, paramagnetic compound Gd(DTPA-BMA) provide a quantitative measure for RNA solvent accessibility and encode distance-to-surface information that correl ...[more]