Dataset Information

Pre-diagnosis diet and survival after a diagnosis of ovarian cancer.

ABSTRACT:

Background

The relationship between diet and survival after ovarian cancer diagnosis is unclear as a result of a limited number of studies and inconsistent findings.

Methods

We examined the association between pre-diagnostic diet and overall survival in a population-based cohort (n=811) of Australian women diagnosed with invasive epithelial ovarian cancer between 2002 and 2005. Diet was measured by validated food frequency questionnaire. Deaths were ascertained up to 31 August 2014 via medical record review and Australian National Death Index linkage. We conducted Cox proportional hazards regression analysis, controlling for diagnosis age, tumour stage, grade and subtype, residual disease, smoking status, body mass index, physical activity, marital status, and energy intake.

Results

We observed improved survival with highest compared with lowest quartile of fibre intake (hazard ratio (HR)=0.69, 95% CI: 0.53-0.90, P-trend=0.002). There was a suggestion of better survival for women with highest compared with lowest intake category of green leafy vegetables (HR=0.79, 95% CI: 0.62-0.99), fish (HR=0.74, 95% CI: 0.57-0.95), poly- to mono-unsaturated fat ratio (HR=0.76, 95% CI: 0.59-0.98), and worse survival with higher glycaemic index (HR=1.28, 95% CI: 1.01-1.65, P-trend=0.03).

Conclusions

The associations we observed between healthy components of diet pre-diagnosis and ovarian cancer survival raise the possibility that dietary choices after diagnosis may improve survival.

SUBMITTER: Playdon MC

PROVIDER: S-EPMC5518850 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Pre-diagnosis diet and survival after a diagnosis of ovarian cancer.

Playdon Mary C MC Nagle Christina M CM Ibiebele Torukiri I TI Ferrucci Leah M LM Protani Melinda M MM Carter Jonathan J Hyde Simon E SE Neesham Deborah D Nicklin James L JL Mayne Susan T ST Webb Penelope M PM

British journal of cancer 20170502 12

<h4>Background</h4>The relationship between diet and survival after ovarian cancer diagnosis is unclear as a result of a limited number of studies and inconsistent findings.<h4>Methods</h4>We examined the association between pre-diagnostic diet and overall survival in a population-based cohort (n=811) of Australian women diagnosed with invasive epithelial ovarian cancer between 2002 and 2005. Diet was measured by validated food frequency questionnaire. Deaths were ascertained up to 31 August 201 ...[more]

PMID: 28463959

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Dataset Information

Pre-diagnosis diet and survival after a diagnosis of ovarian cancer.

Background

Methods

Results

Conclusions

Publications

Pre-diagnosis diet and survival after a diagnosis of ovarian cancer.

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