Transcriptional signatures of influenza A/H1N1-specific IgG memory-like B cell response in older individuals.

ABSTRACT:

Background

Studies suggest that the recall-based humoral immune responses to influenza A/H1N1 originates from activated memory B cells. The aim of this study was to identify baseline, early and late blood transcriptional signatures (in peripheral blood mononuclear cells/PBMCs) associated with memory B cell response following influenza vaccination.

Methods

We used pre- and post-vaccination mRNA-Seq transcriptional profiling on samples from 159 subjects (50-74years old) following receipt of seasonal trivalent influenza vaccine containing the A/California/7/2009/H1N1-like virus, and penalized regression modeling to identify associations with influenza A/H1N1-specific memory B cell ELISPOT response after vaccination.

Results

Genesets and genes (p-value range 7.92E(-08) to

SUBMITTER: Haralambieva IH 

PROVIDER: S-EPMC5520794 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature